What this study looked at
The mucopolysaccharidoses (MPS) are rare inherited disorders that can affect the bones and joints, including the hips. This study described the natural history of hip development in children with MPS I and MPS II through a retrospective radiographic analysis of 88 hips in 44 children, looking at hip migration, femoral head shape and development of the socket at different ages.
Key takeaways
- Both MPS I and MPS II showed high rates of hip migration and deformity of the femoral head.
- Progressive migration was seen in about three-quarters of hips and progressive femoral head deformity in over half, while dysplasia of the socket varied widely and did not change over time.
- Hips tended to be more affected in MPS I than MPS II, and some hips did not deteriorate at all.
Why it matters
Because deterioration is slow and not every hip worsens, there is time to plan a considered, holistic approach to treatment rather than rushing to surgery in every case.
