Background: Down Syndrome is the most common chromosomal condition in the world. There is limited literature on Down Syndrome in the Philippines, as national registries on congenital malformations have not been updated since the 1960s. The objective of this study is to provide evidence-based data on the clinical profiles and specific organ involvement of patients with Down Syndrome.Methods: This descriptive cross-sectional study involves a retrospective review of 66 inpatient records of clinically and cytogenetically diagnosed Down Syndrome patients over the last 5 years. Data analysis was performed using STATA 14 to compute demographic data and prevalence of systemic disorders with a 95% confidence interval.Results: The median age at diagnosis was 1 year. The median parental age at birth was 35 years for both mothers and fathers. Males constituted 59.1% of the patients, while females made up 40.9%. The third birth order was most common, representing 24.3% of cases. Cardiac disorders were the most prevalent at 40.9%, followed by gastrointestinal (33.3%), endocrine (13.6%), and hematologic conditions (12.1%).Conclusion: The median age of the patient upon diagnosis, advanced maternal age, and overall sex ratio correlate with the current global data on Down Syndrome. The most common systemic disorder was cardiac, which is consistent with studies in majority of countries. The clinical profile and the most prevalent systemic disorder in Filipino Down Syndrome patients are at par with the rest of the world.
